Hemolysis of human erythrocytes induced by tamoxifen is related to disruption of membrane structure

Tamoxifen (TAM), the antiestrogenic drug most widely prescribed in the chemotherapy of breast cancer, induces changes in normal discoid shape of erythrocytes and hemolytic anemia. This work evaluates the effects of TAM on isolated human erythrocytes, attempting to identify the underlying mechanisms...

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Bibliographic Details
Main Author: Cruz Silva, M. M. (author)
Other Authors: Madeira, Vítor M. C. (author), Almeida, Leonor M. (author), Custódio, José B. A. (author)
Format: article
Language:eng
Published: 2000
Subjects:
Tamoxifen
Human erythrocyte
Hemolysis
Oxidative stress
Partition coefficient
Membrane disruption
Online Access:http://hdl.handle.net/10316/5810
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/5810

Internet

http://hdl.handle.net/10316/5810

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