siRNA inhibition of endocytic pathways to characterize the cellular uptake mechanisms of folate-functionalized glycol chitosan nanogels

Glycol chitosan nanogels have been widely used in gene, drug, and contrast agent delivery in an effort to improve disease diagnosis and treatment. Herein, we evaluate the internalization mechanisms and intracellular fate of previously described glycol chitosan nanogels decorated with folate to targe...

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Detalhes bibliográficos
Autor principal: Pereira, Paula (author)
Outros Autores: Pedrosa, Sílvia Santos (author), Wymant, Jennifer M. (author), Sayers, Edward (author), Correia, Alexandra (author), Vilanova, Manuel (author), Jones, Arwin T. (author), Gama, F. M. (author)
Formato: article
Idioma:eng
Publicado em: 2015
Assuntos:
Nanogel
Internalization pathways
glycol chitosan nanogel
folate
siRNA transfection
endocytic pathways
intracellular localization
Ciências Médicas::Biotecnologia Médica
Ciências Naturais::Ciências Biológicas
Science & Technology
Texto completo:http://hdl.handle.net/1822/35872
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/35872

Texto Completo

http://hdl.handle.net/1822/35872

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