siRNA inhibition of endocytic pathways to characterize the cellular uptake mechanisms of folate-functionalized glycol chitosan nanogels

Glycol chitosan nanogels have been widely used in gene, drug, and contrast agent delivery in an effort to improve disease diagnosis and treatment. Herein, we evaluate the internalization mechanisms and intracellular fate of previously described glycol chitosan nanogels decorated with folate to targe...

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Bibliographic Details
Main Author: Pereira, Paula (author)
Other Authors: Pedrosa, Sílvia Santos (author), Wymant, Jennifer M. (author), Sayers, Edward (author), Correia, Alexandra (author), Vilanova, Manuel (author), Jones, Arwin T. (author), Gama, F. M. (author)
Format: article
Language:eng
Published: 2015
Subjects:
Nanogel
Internalization pathways
glycol chitosan nanogel
folate
siRNA transfection
endocytic pathways
intracellular localization
Ciências Médicas::Biotecnologia Médica
Ciências Naturais::Ciências Biológicas
Science & Technology
Online Access:http://hdl.handle.net/1822/35872
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/35872

Internet

http://hdl.handle.net/1822/35872

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