Mitochondrial remodeling in human skin fibroblasts from sporadic male Parkinson's disease patients uncovers metabolic and mitochondrial bioenergetic defects

Parkinson's Disease (PD) is characterized by dopaminergic neurodegeneration in the substantia nigra. The exact mechanism by which dopaminergic neurodegeneration occurs is still unknown; however, mitochondrial dysfunction has long been implicated in PD pathogenesis. To investigate the sub-cellul...

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Detalhes bibliográficos
Autor principal: Deus, Cláudia M. (author)
Outros Autores: Pereira, Susana P. (author), Cunha-Oliveira, Teresa (author), Pereira, Francisco B. (author), Raimundo, Nuno Filipe Viegas das Neves (author), Oliveira, Paulo J. (author)
Formato: article
Idioma:por
Publicado em: 2020
Assuntos:
Human skin fibroblasts; Metabolism; Mitochondria; Mitochondrial remodeling; Personalized medicine; Sporadic Parkinson's disease
Aged
Energy Metabolism
Fibroblasts
Galactose
Glucose
Humans
Male
Metabolic Diseases
Middle Aged
Mitochondria
Mitochondrial Diseases
Oxidative Phosphorylation
Oxygen Consumption
Parkinson Disease
Pyruvic Acid
Skin
Substantia Nigra
Texto completo:http://hdl.handle.net/10316/88472
País:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/88472

Texto Completo

http://hdl.handle.net/10316/88472

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