Mitochondrial remodeling in human skin fibroblasts from sporadic male Parkinson's disease patients uncovers metabolic and mitochondrial bioenergetic defects

Parkinson's Disease (PD) is characterized by dopaminergic neurodegeneration in the substantia nigra. The exact mechanism by which dopaminergic neurodegeneration occurs is still unknown; however, mitochondrial dysfunction has long been implicated in PD pathogenesis. To investigate the sub-cellul...

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Bibliographic Details
Main Author: Deus, Cláudia M. (author)
Other Authors: Pereira, Susana P. (author), Cunha-Oliveira, Teresa (author), Pereira, Francisco B. (author), Raimundo, Nuno Filipe Viegas das Neves (author), Oliveira, Paulo J. (author)
Format: article
Language:por
Published: 2020
Subjects:
Human skin fibroblasts; Metabolism; Mitochondria; Mitochondrial remodeling; Personalized medicine; Sporadic Parkinson's disease
Aged
Energy Metabolism
Fibroblasts
Galactose
Glucose
Humans
Male
Metabolic Diseases
Middle Aged
Mitochondria
Mitochondrial Diseases
Oxidative Phosphorylation
Oxygen Consumption
Parkinson Disease
Pyruvic Acid
Skin
Substantia Nigra
Online Access:http://hdl.handle.net/10316/88472
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/88472

Internet

http://hdl.handle.net/10316/88472

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