Ion channel blockers as antimicrobial agents, efflux inhibitors, and enhancers of macrophage killing activity against drug resistant mycobacterium tuberculosis

Given the ability of M. tuberculosis to survive as an intracellular pathogen and its propensity to develop resistance to the existing antituberculosis drugs, its treatment requires new approaches. Here the antimycobacterial properties of verapamil, thioridazine, chlorpromazine, flupenthixol and halo...

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Bibliographic Details
Main Author: Machado, Diana (author)
Other Authors: Pires, David (author), Perdigão, João (author), Couto, Isabel (author), Portugal, Isabel (author), Martins, Marta (author), Amaral, Leonard (author), Anes, Elsa (author), Viveiros, Miguel (author)
Format: article
Language:eng
Published: 2018
Subjects:
Biochemistry, Genetics and Molecular Biology(all)
Microbiology
Infectious Diseases
SDG 3 - Good Health and Well-being
Online Access:https://doi.org/10.1371/journal.pone.0149326
Country:Portugal
Oai:oai:run.unl.pt:10362/36611

Internet

https://doi.org/10.1371/journal.pone.0149326

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