Ion channel blockers as antimicrobial agents, efflux inhibitors, and enhancers of macrophage killing activity against drug resistant mycobacterium tuberculosis

Given the ability of M. tuberculosis to survive as an intracellular pathogen and its propensity to develop resistance to the existing antituberculosis drugs, its treatment requires new approaches. Here the antimycobacterial properties of verapamil, thioridazine, chlorpromazine, flupenthixol and halo...

ver descrição completa

Detalhes bibliográficos
Autor principal: Machado, Diana (author)
Outros Autores: Pires, David (author), Perdigão, João (author), Couto, Isabel (author), Portugal, Isabel (author), Martins, Marta (author), Amaral, Leonard (author), Anes, Elsa (author), Viveiros, Miguel (author)
Formato: article
Idioma:eng
Publicado em: 2018
Assuntos:
Texto completo:https://doi.org/10.1371/journal.pone.0149326
País:Portugal
Oai:oai:run.unl.pt:10362/36611