Tumor-targeted Chlorotoxin-coupled Nanoparticles for Nucleic Acid Delivery to Glioblastoma Cells: A Promising System for Glioblastoma Treatment

The present work aimed at the development and application of a lipid-based nanocarrier for targeted delivery of nucleic acids to glioblastoma (GBM). For this purpose, chlorotoxin (CTX), a peptide reported to bind selectively to glioma cells while showing no affinity for non-neoplastic cells, was cov...

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Detalhes bibliográficos
Autor principal: Costa, Pedro M. (author)
Outros Autores: Cardoso, Ana L. (author), Mendonça, Liliana S. (author), Serani, Angelo (author), Custódia, Carlos (author), Conceição, Mariana (author), Simões, Sérgio (author), Moreira, João N. (author), Almeida, Luis Pereira de (author), Lima, M. C. P. de (author)
Formato: article
Idioma:eng
Publicado em: 2013
Assuntos:
chlorotoxin
glioblastoma
liposome
miR-21
stable nucleic acid lipid particle
Texto completo:http://hdl.handle.net/10316/25539
País:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/25539

Texto Completo

http://hdl.handle.net/10316/25539

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