Tumor-targeted Chlorotoxin-coupled Nanoparticles for Nucleic Acid Delivery to Glioblastoma Cells: A Promising System for Glioblastoma Treatment

The present work aimed at the development and application of a lipid-based nanocarrier for targeted delivery of nucleic acids to glioblastoma (GBM). For this purpose, chlorotoxin (CTX), a peptide reported to bind selectively to glioma cells while showing no affinity for non-neoplastic cells, was cov...

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Bibliographic Details
Main Author: Costa, Pedro M. (author)
Other Authors: Cardoso, Ana L. (author), Mendonça, Liliana S. (author), Serani, Angelo (author), Custódia, Carlos (author), Conceição, Mariana (author), Simões, Sérgio (author), Moreira, João N. (author), Almeida, Luis Pereira de (author), Lima, M. C. P. de (author)
Format: article
Language:eng
Published: 2013
Subjects:
chlorotoxin
glioblastoma
liposome
miR-21
stable nucleic acid lipid particle
Online Access:http://hdl.handle.net/10316/25539
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/25539

Internet

http://hdl.handle.net/10316/25539

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