Critical perspective on the consequences of the limited availability of kinetic data in metabolic dynamic modeling

Detailed kinetic models at the network reaction level are usually constructed using enzymatic mechanistic rate equations and the associated kinetic parameters. However, during the cellular life cycle thousands of different reactions occur, which makes it very difficult to build a detailed large-scal...

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Bibliographic Details
Main Author: Costa, Rafael S. (author)
Other Authors: Machado, C. D. (author), Rocha, I. (author), Ferreira, Eugénio C. (author)
Format: article
Language:eng
Published: 2011
Subjects:
Online Access:https://hdl.handle.net/1822/16719
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/16719