Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation

HIV-1 Vif (viral infectivity factor) protein overcomes the antiviral activity of the DNA deaminase APOBEC3G by targeting it for proteasomal degradation. We report here that Vif targets APOBEC3G for degradation by forming an SCF-like E3 ubiquitin ligase co

Bibliographic Details
Main Author: Mehle, A (author)
Other Authors: Goncalves, J (author), Santa-Marta, M (author), McPike, M (author), Gabuzda, D (author)
Format: article
Language:eng
Published: 2015
Subjects:
Cell Biology
Developmental Biology
Genetics & Heredity
Online Access:http://hdl.handle.net/10451/21601
Country:Portugal
Oai:oai:repositorio.ul.pt:10451/21601

Internet

http://hdl.handle.net/10451/21601

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