Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation

HIV-1 Vif (viral infectivity factor) protein overcomes the antiviral activity of the DNA deaminase APOBEC3G by targeting it for proteasomal degradation. We report here that Vif targets APOBEC3G for degradation by forming an SCF-like E3 ubiquitin ligase co

Detalhes bibliográficos
Autor principal: Mehle, A (author)
Outros Autores: Goncalves, J (author), Santa-Marta, M (author), McPike, M (author), Gabuzda, D (author)
Formato: article
Idioma:eng
Publicado em: 2015
Assuntos:
Cell Biology
Developmental Biology
Genetics & Heredity
Texto completo:http://hdl.handle.net/10451/21601
País:Portugal
Oai:oai:repositorio.ul.pt:10451/21601

Texto Completo

http://hdl.handle.net/10451/21601

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