Common polygenic variation contributes to risk of schizophrenia and bipolardisorder

Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80%. We performed a genome-wide association study of 3,322 European individuals with schizophrenia and 3,587 controls. H...

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Main Author: Purcell, S. M. (author)
Other Authors: Wray, N. R. (author), Stone, J. L. (author), Visscher, P. M. (author), O'Donovan, M. C. (author), Sullivan, P. F. (author), Sklar, P. (author), Leader, S. M. (author), Ruderfer, D. M. (author), McQuillin, A. (author), Morris, D. W. (author), O'Dushlaine, C. T. (author), Corvin, A. (author), Holmans, P. A. (author), Macgregor, S. (author), Gurling, H. (author), Blackwood, D. H. (author), Craddock, N. J. (author), Gill, M. (author), Hultman, C. M. (author), Kirov, G. K. (author), Lichtenstein, P. (author), Muir, W. J. (author), Owen, M. J. (author), Pato, Carlos N. (author), Scolnick, E. M. (author), St Clair, D. (author), Williams, N. M. (author), Georgieva, L. (author), Nikolov, I. (author), Norton, N. (author), Williams, H. (author), Toncheva, D. (author), Milanova, V. (author), Helander, E. F. (author), Kenny, E. (author), Quinn, E. M. (author), Choudhury, K. (author), Datta, S. (author), Pimm, J. (author), Thirumalai, S. (author), Puri, V. (author), Krasucki, R. (author), Lawrence, J. (author), Quested, D. (author), Bass, N. (author), Crombie, C. (author), Fraser, G. (author), Leh, K. S. (author), Walker, N. (author), Black-wood, D. H. (author), McGhee, K. A. (author), Pickard, B. (author), Malloy, P. (author), Maclean, A. W. (author), Van Beck, M. (author), Pato, Michele T. (author), Medeiros, Helena (author), Middleton, Frank A. (author), Carvalho, Célia (author), Morley, C. (author), Fanous, Ayman H. (author), Conti, D. (author), Knowles, James A. (author), Ferreira, Carlos Paz (author), Macedo, António (author), Kirby, A. N. (author), Ferreira, M. A. (author), Daly, M. J. (author), Cham-bert, K. (author), Kuruvilla, F. (author), Gabriel, S. B. (author), Ardlie, K. (author), Moran, J. L. (author)
Format: article
Language:eng
Published: 2017
Subjects:
Online Access:http://hdl.handle.net/10400.3/3997
Country:Portugal
Oai:oai:repositorio.uac.pt:10400.3/3997