Rab27a targeting to melanosomes requires nucleotide exchange but not effector binding

Rab GTPases are important determinants of organelle identity and regulators of vesicular transport pathways. Consequently, each Rab occupies a highly specific subcellular localization. However, the precise mechanisms governing Rab targeting remain unclear. Guanine nucleotide exchange factors (GEFs),...

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Bibliographic Details
Main Author: Tarafder, Abul K. (author)
Other Authors: Wasmeier, Christina (author), Figueiredo, Ana C. (author), Booth, Antonia E.G. (author), Orihara, Asumi (author), Ramalho, Jose S. (author), Hume, Alistair N. (author), Seabra, Miguel C. (author)
Format: article
Language:eng
Published: 2022
Subjects:
Effectors
Guanine nucleotide exchange factor
Melanosome
Rab
Targeting
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology
Online Access:http://hdl.handle.net/10362/146412
Country:Portugal
Oai:oai:run.unl.pt:10362/146412

Internet

http://hdl.handle.net/10362/146412

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