Rab27a targeting to melanosomes requires nucleotide exchange but not effector binding

Rab GTPases are important determinants of organelle identity and regulators of vesicular transport pathways. Consequently, each Rab occupies a highly specific subcellular localization. However, the precise mechanisms governing Rab targeting remain unclear. Guanine nucleotide exchange factors (GEFs),...

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Detalhes bibliográficos
Autor principal: Tarafder, Abul K. (author)
Outros Autores: Wasmeier, Christina (author), Figueiredo, Ana C. (author), Booth, Antonia E.G. (author), Orihara, Asumi (author), Ramalho, Jose S. (author), Hume, Alistair N. (author), Seabra, Miguel C. (author)
Formato: article
Idioma:eng
Publicado em: 2022
Assuntos:
Effectors
Guanine nucleotide exchange factor
Melanosome
Rab
Targeting
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology
Texto completo:http://hdl.handle.net/10362/146412
País:Portugal
Oai:oai:run.unl.pt:10362/146412

Texto Completo

http://hdl.handle.net/10362/146412

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