Upstream Open Reading Frames and Human Genetic Disease

Abstract: In many eukaryotic messenger ribonucleic acids (mRNAs) one or more short upstream open reading frames (uORFs) precede the initiation codon of the main coding region. For example, in human cells, uORFs are present in about half of the transcripts. Emerging ribosome profiling and peptidomics...

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Bibliographic Details
Main Author: Barbosa, Cristina (author)
Other Authors: Onofre, Claudia (author), Romão, Luísa (author)
Format: bookPart
Language:eng
Published: 2015
Subjects:
Genómica Funcional e Estrutural
Upstream Open Reading Frame (uORF)
Protein Synthesis
Polypeptide
Translational Control
Gene Expression Regulation
Human Genetic Disease
Doenças Genéticas
Online Access:http://hdl.handle.net/10400.18/2749
Country:Portugal
Oai:oai:repositorio.insa.pt:10400.18/2749

Internet

http://hdl.handle.net/10400.18/2749

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