Shedding light on miRNA targeting through structure

In miRNAs, it is known that seed pairing is an important parameter for targeting, but there are still missing links on why it targets a certain mRNA and how the decision between degradation or translation repression is made. In our work, we use liquid state NMR spectroscopy, EMSA and UV melting expe...

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Bibliographic Details
Main Author: Silva, Luis Filipe Santos Pereira Fernandes da (author)
Format: masterThesis
Language:eng
Published: 2020
Subjects:
miRNA
mRNA
seed sequence
transient
simulation
EMSA
Domínio/Área Científica::Engenharia e Tecnologia::Engenharia Química
Online Access:http://hdl.handle.net/10362/29427
Country:Portugal
Oai:oai:run.unl.pt:10362/29427

Internet

http://hdl.handle.net/10362/29427

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