Synthesis of new proteomimetic quinazolinone alkaloids and evaluation of their neuroprotective and antitumor effects

New quinazolinone derivatives of the marine-derived alkaloids fiscalin B (3) and fumiquinazoline G (1), with neuroprotective and antitumor effects, were synthesized. Eleven quinazolinone-containing indole alkaloids were synthesized, proceeding the anti analogs via a one-pot method, and the syn analo...

Full description

Bibliographic Details
Main Author: Long, S (author)
Other Authors: Resende, D (author), Kijjoa, A (author), Silva, A (author), Fernandes, R (author), Xavier, CPR (author), Vasconcelos, MH (author), Sousa, E (author), Pinto, M (author)
Format: article
Language:eng
Published: 2019
Subjects:
Antitumor
Enantioselectivity
Fiscalin B
Fumiquinazoline
Neuroprotection
Quinazolinones
Online Access:https://hdl.handle.net/10216/136283
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/136283

Internet

https://hdl.handle.net/10216/136283

Similar Items