Synthesis of new proteomimetic quinazolinone alkaloids and evaluation of their neuroprotective and antitumor effects

New quinazolinone derivatives of the marine-derived alkaloids fiscalin B (3) and fumiquinazoline G (1), with neuroprotective and antitumor effects, were synthesized. Eleven quinazolinone-containing indole alkaloids were synthesized, proceeding the anti analogs via a one-pot method, and the syn analo...

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Detalhes bibliográficos
Autor principal: Long, S (author)
Outros Autores: Resende, D (author), Kijjoa, A (author), Silva, A (author), Fernandes, R (author), Xavier, CPR (author), Vasconcelos, MH (author), Sousa, E (author), Pinto, M (author)
Formato: article
Idioma:eng
Publicado em: 2019
Assuntos:
Antitumor
Enantioselectivity
Fiscalin B
Fumiquinazoline
Neuroprotection
Quinazolinones
Texto completo:https://hdl.handle.net/10216/136283
País:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/136283

Texto Completo

https://hdl.handle.net/10216/136283

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