The role of pfmdr1 in Plasmodium falciparum tolerance to artemether-lumefantrine in Africa

Objective Artemether-lumefantrine (AL), presently the most favoured combination therapy against uncomplicated Plasmodium falciparum malaria in Africa, has recently shown to select for the pfmdr1 86N allele. The objective of this study was to search for the selection of other mutations potentially in...

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Bibliographic Details
Main Author: Sisowath, Christin (author)
Other Authors: Ferreira, Pedro E. (author), Bustamante, Leyla Y. (author), Dahlstrom, Sabina (author), Martensson, Andreas (author), Bjorkman, Anders (author), Krishna, Sanjeev (author), Gil, José Pedro (author)
Format: article
Language:eng
Published: 2018
Subjects:
Sub-Saharan Africa
Mefloquine resistance
Increased sensitivity
Gene
Selection
Malaria
Amplification
Halofantrine
Amodiaquine
Mutations
Online Access:http://hdl.handle.net/10400.1/11582
Country:Portugal
Oai:oai:sapientia.ualg.pt:10400.1/11582

Internet

http://hdl.handle.net/10400.1/11582

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