5-(Hydroxyphenyl)-γ-valerolactone-sulfate, a key microbial metabolite of flavan-3-ols, is able to reach the brain

Phenolic compounds have been recognized as promising compounds for the prevention of chronic diseases, including neurodegenerative ones. However, phenolics like flavan-3-ols (F3O) are poorly absorbed along the gastrointestinal tract and structurally rearranged by gut microbiota, yielding smaller and...

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Bibliographic Details
Main Author: Angelino, Donato (author)
Other Authors: Carregosa, Diogo (author), Domenech-Coca, Cristina (author), Savi, Monia (author), Figueira, Inês (author), Brindani, Nicoletta (author), Jang, Saebyeol (author), Lakshman, Sukla (author), Molokin, Aleksey (author), Urban, Joseph F. (author), Davis, Cindy D. (author), Brito, Maria Alexandra (author), Kim, Kwang Sik (author), Brighenti, Furio (author), Curti, Claudio (author), Bladé, Cinta (author), Del Bas, Josep M. (author), Stilli, Donatella (author), Solano-Aguilar, Gloria I. (author), Dos Santos, Claudia Nunes (author), Del Rio, Daniele (author), Mena, Pedro (author)
Format: article
Language:eng
Published: 2019
Subjects:
Blood brain barrier
Catechin
Flavan-3-ol
Gut
Metabolites
Neurodegenerative disease
Permeability
Polyphenols
Proanthocyanidin
Valerolactone
Food Science
Nutrition and Dietetics
Online Access:https://doi.org/10.3390/nu11112678
Country:Portugal
Oai:oai:run.unl.pt:10362/88419

Internet

https://doi.org/10.3390/nu11112678

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