Mechanism of Antifungal Activity by 5-Aminoimidazole-4-Carbohydrazonamide Derivatives against Candida albicans and Candida krusei

Systemic mycoses are one major cause of morbidity/mortality among immunocompromised/debilitated individuals. Studying the mechanism of action is a strategy to develop safer/potent antifungals, warning resistance emergence. The major goal of this study was to elucidate the mechanism of action of thre...

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Detalhes bibliográficos
Autor principal: Cerqueira, Fátima (author)
Outros Autores: Maia, Marta (author), Gabriel, Carla (author), Medeiros, Rui (author), Cravo, Sara (author), Ribeiro, Ana Isabel (author), Dantas, Daniela (author), Dias, Alice Maria (author), Saraiva, Lucília (author), Raimundo, Liliana (author), Pinto, Eugénia (author)
Formato: article
Idioma:eng
Publicado em: 2021
Assuntos:
Candida sp
antifungals
(Z)-5-amino-N&#8217
-aryl-1-methyl-1H-imidazole-4-carbohydrazonamides
mechanisms of action
reactive oxygen species
ergosterol
dimorphic transition
metabolic viability
(Z)-5-amino-N’-aryl-1-methyl-1H-imidazole-4-carbohydrazonamides
Science & Technology
Texto completo:http://hdl.handle.net/1822/72539
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/72539

Texto Completo

http://hdl.handle.net/1822/72539

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