Mechanism of Antifungal Activity by 5-Aminoimidazole-4-Carbohydrazonamide Derivatives against Candida albicans and Candida krusei

Systemic mycoses are one major cause of morbidity/mortality among immunocompromised/debilitated individuals. Studying the mechanism of action is a strategy to develop safer/potent antifungals, warning resistance emergence. The major goal of this study was to elucidate the mechanism of action of thre...

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Bibliographic Details
Main Author: Cerqueira, Fátima (author)
Other Authors: Maia, Marta (author), Gabriel, Carla (author), Medeiros, Rui (author), Cravo, Sara (author), Ribeiro, Ana Isabel (author), Dantas, Daniela (author), Dias, Alice Maria (author), Saraiva, Lucília (author), Raimundo, Liliana (author), Pinto, Eugénia (author)
Format: article
Language:eng
Published: 2021
Subjects:
Candida sp
antifungals
(Z)-5-amino-N&#8217
-aryl-1-methyl-1H-imidazole-4-carbohydrazonamides
mechanisms of action
reactive oxygen species
ergosterol
dimorphic transition
metabolic viability
(Z)-5-amino-N’-aryl-1-methyl-1H-imidazole-4-carbohydrazonamides
Science & Technology
Online Access:http://hdl.handle.net/1822/72539
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/72539

Internet

http://hdl.handle.net/1822/72539

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