shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity

Alpha-Synuclein (aSyn) misfolding and aggregation is common in several neurodegenerative diseases, including Parkinson's disease and dementia with Lewy bodies, which are known as synucleinopathies. Accumulating evidence suggests that secretion and cell-to-cell trafficking of pathological forms...

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Detalhes bibliográficos
Autor principal: Gonçalves, Susana A (author)
Outros Autores: Macedo, Diana (author), Raquel, Helena (author), Simões, Pedro D (author), Giorgini, Flaviano (author), Ramalho, José S (author), Barral, Duarte C (author), Ferreira Moita, Luís (author), Outeiro, Tiago Fleming (author)
Formato: article
Idioma:eng
Publicado em: 2016
Assuntos:
Secretion
Hyperexpression techniques
Oligomers
Toxicity
Cytotoxicity
Immunoblotting
Immunocytochemistry
Fluorescence microscopy
Texto completo:http://hdl.handle.net/10400.7/591
País:Portugal
Oai:oai:arca.igc.gulbenkian.pt:10400.7/591

Texto Completo

http://hdl.handle.net/10400.7/591

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