shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity

Alpha-Synuclein (aSyn) misfolding and aggregation is common in several neurodegenerative diseases, including Parkinson's disease and dementia with Lewy bodies, which are known as synucleinopathies. Accumulating evidence suggests that secretion and cell-to-cell trafficking of pathological forms...

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Bibliographic Details
Main Author: Gonçalves, Susana A (author)
Other Authors: Macedo, Diana (author), Raquel, Helena (author), Simões, Pedro D (author), Giorgini, Flaviano (author), Ramalho, José S (author), Barral, Duarte C (author), Ferreira Moita, Luís (author), Outeiro, Tiago Fleming (author)
Format: article
Language:eng
Published: 2016
Subjects:
Secretion
Hyperexpression techniques
Oligomers
Toxicity
Cytotoxicity
Immunoblotting
Immunocytochemistry
Fluorescence microscopy
Online Access:http://hdl.handle.net/10400.7/591
Country:Portugal
Oai:oai:arca.igc.gulbenkian.pt:10400.7/591

Internet

http://hdl.handle.net/10400.7/591

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