Cell fate potentials and switching kinetics uncovered in a classic bistable genetic switch

Bistable switches are common gene regulatory motifs directing two mutually exclusive cell fates. Theoretical studies suggest that bistable switches are sufficient to encode more than two cell fates without rewiring the circuitry due to the non-equilibrium, heterogeneous cellular environment. However...

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Bibliographic Details
Main Author: Fang, Xiaona (author)
Other Authors: Liu, Qiong (author), Bohrer, Christopher (author), Hensel, Zach (author), Han, Wei (author), Wang, Jin (author), Xiao, Jie (author)
Format: article
Language:eng
Published: 2019
Subjects:
Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)
Physics and Astronomy(all)
Online Access:https://doi.org/10.1038/s41467-018-05071-1
Country:Portugal
Oai:oai:run.unl.pt:10362/67798

Internet

https://doi.org/10.1038/s41467-018-05071-1

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