Kinetochore-microtubule interactions "in check" by Bub1, Bub3 and BubR1: the dual task of attaching and signalling

The spindle assembly checkpoint (SAC) prevents anaphase onset until all chromosomes accomplish proper bipolar attachments to the mitotic spindle and come under tension, thereby ensuring the fidelity of chromosome segregation. Despite significant advances in our understanding of SAC signalling, a cle...

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Bibliographic Details
Main Author: Logarinho, Elsa (author)
Other Authors: Bousbaa, Hassan (author)
Format: article
Language:eng
Published: 2008
Subjects:
Animals
Cell Cycle Proteins
Humans
Kinetochores
Microtubules
Poly-ADP-Ribose Binding Proteins
Prometaphase
Protein-Serine-Threonine Kinases
Signal Transduction
Spindle Apparatus
Spindle assembly checkpoint
Kinetochore-microtubule attachments
BubR1
Bub1
Bub3
Science & Technology
Online Access:http://hdl.handle.net/1822/61471
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/61471

Internet

http://hdl.handle.net/1822/61471

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