The Warburg effect in mycobacterial granulomas is dependent on the recruitment and activation of macrophages by interferon-γ

Granulomas are the hallmark of mycobacterial disease. Here, we demonstrate that both the cell recruitment and the increased glucose consumption in granulomatous infiltrates during Mycobacterium avium infection are highly dependent on interferon-y (IFN-y). Mycobacterium avium-infected mice lacking IF...

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Detalhes bibliográficos
Autor principal: Appelberg, Rui (author)
Outros Autores: Moreira, Diana (author), Silva, Palmira Conceição Araújo Barreira (author), Borges, Margarida (author), Silva, Letícia (author), Dinis-Oliveira, Ricardo Jorge (author), Resende, Mariana (author), Neves, Margarida Correia (author), Jordan, Michael B. (author), Ferreira, Nuno C. (author), Abrunhosa, Antero J. (author), Silvestre, Ricardo Jorge Leal (author)
Formato: article
Idioma:eng
Publicado em: 2015
Assuntos:
Glycolysis
Infection
Interferon-γ
Macrophages
Mycobacteria
interferon-gamma
Interferon-?
Ciências Médicas::Ciências da Saúde
Science & Technology
Texto completo:http://hdl.handle.net/1822/40065
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/40065

Texto Completo

http://hdl.handle.net/1822/40065

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