The Warburg effect in mycobacterial granulomas is dependent on the recruitment and activation of macrophages by interferon-γ

Granulomas are the hallmark of mycobacterial disease. Here, we demonstrate that both the cell recruitment and the increased glucose consumption in granulomatous infiltrates during Mycobacterium avium infection are highly dependent on interferon-y (IFN-y). Mycobacterium avium-infected mice lacking IF...

Full description

Bibliographic Details
Main Author: Appelberg, Rui (author)
Other Authors: Moreira, Diana (author), Silva, Palmira Conceição Araújo Barreira (author), Borges, Margarida (author), Silva, Letícia (author), Dinis-Oliveira, Ricardo Jorge (author), Resende, Mariana (author), Neves, Margarida Correia (author), Jordan, Michael B. (author), Ferreira, Nuno C. (author), Abrunhosa, Antero J. (author), Silvestre, Ricardo Jorge Leal (author)
Format: article
Language:eng
Published: 2015
Subjects:
Glycolysis
Infection
Interferon-γ
Macrophages
Mycobacteria
interferon-gamma
Interferon-?
Ciências Médicas::Ciências da Saúde
Science & Technology
Online Access:http://hdl.handle.net/1822/40065
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/40065

Internet

http://hdl.handle.net/1822/40065

Similar Items