Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models

Different neurodegenerative diseases are caused by aberrant elongation of repeated glutamine sequences normally found in particular human proteins. Although the proteins involved are ubiquitously distributed in human tissues, toxicity targets only defined neuronal populations. Changes caused by an e...

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Bibliographic Details
Main Author: Matos, C (author)
Other Authors: Nóbrega, C (author), Louros, S (author), Almeida, B (author), Ferreiro, E (author), Valero, J (author), Almeida, L (author), Macedo-Ribeiro, S (author), Carvalho, A (author)
Format: article
Language:eng
Published: 2016
Subjects:
Machado-joseph-disease
Protein ataxin-3
Polyglutamine disease
Mutant ataxin-3
Rat model
Huntingtin phosphorylation
Clinical-features
Expanded ataxin-3
Repeat expansion
Transgenic mice
Online Access:http://hdl.handle.net/10216/108249
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/108249

Internet

http://hdl.handle.net/10216/108249

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