Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models

Different neurodegenerative diseases are caused by aberrant elongation of repeated glutamine sequences normally found in particular human proteins. Although the proteins involved are ubiquitously distributed in human tissues, toxicity targets only defined neuronal populations. Changes caused by an e...

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Detalhes bibliográficos
Autor principal: Matos, C (author)
Outros Autores: Nóbrega, C (author), Louros, S (author), Almeida, B (author), Ferreiro, E (author), Valero, J (author), Almeida, L (author), Macedo-Ribeiro, S (author), Carvalho, A (author)
Formato: article
Idioma:eng
Publicado em: 2016
Assuntos:
Machado-joseph-disease
Protein ataxin-3
Polyglutamine disease
Mutant ataxin-3
Rat model
Huntingtin phosphorylation
Clinical-features
Expanded ataxin-3
Repeat expansion
Transgenic mice
Texto completo:http://hdl.handle.net/10216/108249
País:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/108249

Texto Completo

http://hdl.handle.net/10216/108249

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