Carvedilol-mediated antioxidant protection against doxorubicin-induced cardiac mitochondrial toxicity

The cardiotoxicity associated with doxorubicin (DOX) therapy limits the total cumulative dose and therapeutic success of active anticancer chemotherapy. Cardiac mitochondria are implicated as primary targets for DOX toxicity, which is believed to be mediated by the generation of highly reactive free...

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Detalhes bibliográficos
Autor principal: Oliveira, Paulo J. (author)
Outros Autores: Bjork, James A. (author), Santos, Maria S. (author), Leino, Richard L. (author), Froberg, M. Kent (author), Moreno, António J. (author), Wallace, Kendall B. (author)
Formato: article
Idioma:eng
Publicado em: 2004
Assuntos:
Mitochondria
Doxorubicin
Carvedilol
Atenolol
Permeability transition pore
Oxidative damage
Mitochondrionopathy
Texto completo:http://hdl.handle.net/10316/5379
País:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/5379

Texto Completo

http://hdl.handle.net/10316/5379

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