Carvedilol-mediated antioxidant protection against doxorubicin-induced cardiac mitochondrial toxicity

The cardiotoxicity associated with doxorubicin (DOX) therapy limits the total cumulative dose and therapeutic success of active anticancer chemotherapy. Cardiac mitochondria are implicated as primary targets for DOX toxicity, which is believed to be mediated by the generation of highly reactive free...

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Bibliographic Details
Main Author: Oliveira, Paulo J. (author)
Other Authors: Bjork, James A. (author), Santos, Maria S. (author), Leino, Richard L. (author), Froberg, M. Kent (author), Moreno, António J. (author), Wallace, Kendall B. (author)
Format: article
Language:eng
Published: 2004
Subjects:
Mitochondria
Doxorubicin
Carvedilol
Atenolol
Permeability transition pore
Oxidative damage
Mitochondrionopathy
Online Access:http://hdl.handle.net/10316/5379
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/5379

Internet

http://hdl.handle.net/10316/5379

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