Stimulation of neural stem cell proliferation by inhibition of phosphodiesterase 5

The involvement of nitric oxide (NO) and cyclic GMP (cGMP) in neurogenesis has been progressively unmasked over the last decade. Phosphodiesterase 5 (PDE5) specifically degrades cGMP and is highly abundant in the mammalian brain. Inhibition of cGMP hydrolysis by blocking PDE5 is a possible strategy...

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Bibliographic Details
Main Author: Santos, Ana Isabel (author)
Other Authors: Carreira, Bruno P. (author), Nobre, Rui Jorge (author), Carvalho, Caetana M. (author), Araújo, Inês (author)
Format: article
Language:eng
Published: 2018
Subjects:
Cyclic nucleotide phosphodiesterase
Nitric oxide synthase
Camp specific phosphodiesterase
Focal cerebral ischemia
Protein kinase G
Subventricular zone
Functional recovery
Dentate gyrus
Adult neurogenesis
Olfactory bulb
Online Access:http://hdl.handle.net/10400.1/12045
Country:Portugal
Oai:oai:sapientia.ualg.pt:10400.1/12045

Internet

http://hdl.handle.net/10400.1/12045

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