Heteroarylether 1,3-diarylureas in the thieno[3,2-d]pyrimidine series as VEGFR2 tyrosine Kinase inhibitors: synthesis, docking studies, enzymatic and cellular assays

A number of thienopyrimidines derivatives have shown potent YEGFR2 (Vascular Endothelium Growth Factor Receptor2) inhibition activity [ 1]. YEGF is a surrogate marker of angiogenesis that activates VEGFR2 in endothelial cells. VEGF induces proliferation, migration and anastomosis of these cells. Her...

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Bibliographic Details
Main Author: Queiroz, Maria João R.P. (author)
Other Authors: Peixoto, Daniela (author), Soares, Pedro (author), Abreu, Rui M.V. (author), Froufe, Hugo J.C. (author), Calhelha, Ricardo C. (author), Ferreira, Isabel C.F.R. (author), Costa, Raquel (author), Soares, Raquel (author)
Format: conferenceObject
Language:eng
Published: 2012
Online Access:http://hdl.handle.net/10198/7357
Country:Portugal
Oai:oai:bibliotecadigital.ipb.pt:10198/7357

Internet

http://hdl.handle.net/10198/7357

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