Hepcidin is regulated by promoter-associated histone acetylation and HDAC3

Hepcidin regulates systemic iron homeostasis. Suppression of hepcidin expression occurs physiologically in iron deficiency and increased erythropoiesis but is pathologic in thalassemia and hemochromatosis. Here we show that epigenetic events govern hepcidin expression. Erythropoiesis and iron defici...

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Bibliographic Details
Main Author: Pasricha, S. (author)
Other Authors: Lim, P. (author), Duarte, T. (author), Casu, C. (author), Oosterhuis, D. (author), Mleczko-Sanecka, K. (author), Suciu, M. (author), Da Silva, A. (author), Al-Hourani, K. (author), Arezes, J. (author), McHugh, K. (author), Gooding, S. (author), Frost, J. (author), Wray, K. (author), Santos, A. (author), Porto, G. (author), Repapi, E. (author), Gray, N. (author), Draper, S. (author), Ashley, N. (author), Soilleux, E. (author), Olinga, P. (author), Muckenthaler, M. (author), Hughes, J. (author), Rivella, S. (author), Milne, T. (author), Armitage, A. (author), Drakesmith, H. (author)
Format: article
Language:eng
Published: 2018
Online Access:http://hdl.handle.net/10400.16/2232
Country:Portugal
Oai:oai:repositorio.chporto.pt:10400.16/2232

Internet

http://hdl.handle.net/10400.16/2232

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