| Resumo: | Bones are dynamic tissues that undergo a constant and complex remodeling process. In a healthy bone, the remodeling process involves the coupled action of bone formation, by osteoblasts and bone resorption, by osteoclasts. In some cases, however, there is an imbalance between these two actions, resulting in bone tissue disorders that are an important public health problem. Nowadays, there are already several treatments to help manage bone tissue disorders. Within those, bisphosphonates (BPs) are one of the most used class of drugs due to their remarkable high affinity to hydroxyapatite in bone. Along with BPs it has been common for physicians to prescribe mineral supplements, such as calcium. Nonetheless, such combined therapy is sometimes overlooked by the patients, compromising thus the efficacy of the treatment. In response to this problem, this work aimed at designing multi-component coordination compounds composed of bisphosphonates, as organic linkers (BP alendronate, the active ingredient of the commercial drug Fosamax®), in coordination with mineral supplements, as metal centers (calcium, magnesium and/or strontium). Different combinations of these building blocks allowed the preparation of several coordination compounds, with distinct structural, physico-chemical and biological properties. Altogether, the results from this work are a step further to bring this type of compounds closer to a future therapeutic application in the management of bone tissue disorders.
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