Pharmacological evaluation and SAR studies of oxindole derivatives as cholinesterase inhibitors

From a screening study of various potential inhibitors for cholinesterases (ChEs), compound (rac)-1(4-((3-hydroxy-2-oxo-3-phenylindolin-1-yl)methyl) piperidin-1-ium chloride) showed an IC50 of 18 mu M for butyrylcholinesterase (BuChE). Herein we present a toxicological and pharmacological evaluation...

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Bibliographic Details
Main Author: BURKE, Anthony (author)
Other Authors: Lopez, Oscar (author), Elisabete, Carreiro (author), Patricia, Bacalhau (author), Rita, Guedes (author), Fatima, Candeias (author), Rosário, Martins (author), Teresa, Caldeira (author), Luis, Fernandes (author)
Format: article
Language:eng
Published: 2020
Subjects:
Alzheimer's disease
oxindole
cholinesterase
docking
Online Access:http://hdl.handle.net/10174/26632
Country:Portugal
Oai:oai:dspace.uevora.pt:10174/26632

Internet

http://hdl.handle.net/10174/26632

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