Structure-function studies of BPP-BrachyNH 2 and synthetic analogues thereof with Angiotensin I-Converting Enzyme

The vasoactive proline-rich oligopeptide termed BPP-BrachyNH2 (H-WPPPKVSP-NH2) induces in vitro inhibitory activity of angiotensin I-converting enzyme (ACE) in rat blood serum. In the present study, the removal of N-terminal tryptophan or C-terminal proline from BPP-BrachyNH2 was investigated in ord...

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Bibliographic Details
Main Author: Arcanjo, Daniel D.R. (author)
Other Authors: Vasconcelos, Andreanne G. (author), Nascimento, Lucas A. (author), Mafud, Ana Carolina (author), Plácido, Alexandra (author), Alves, Michel M.M. (author), Delerue-Matos, Cristina (author), Bemquerer, Marcelo P. (author), Vale, Nuno (author), Gomes, Paula (author), Oliveira, Eduardo B. (author), Lima, Francisco C.A. (author), Mascarenhas, Yvonne P. (author), Carvalho, Fernando Aécio A. (author), Simonsen, Ulf (author), Ramos, Ricardo M. (author), Leite, José Roberto S.A. (author)
Format: article
Language:eng
Published: 2019
Subjects:
Docking
Molecular dynamics simulations
Molecular mechanics
Poisson-Boltzmann surface area
g_mmpbsa
proline-Rich oligopeptide
Toxicological prediction
Online Access:http://hdl.handle.net/10400.22/13537
Country:Portugal
Oai:oai:recipp.ipp.pt:10400.22/13537

Internet

http://hdl.handle.net/10400.22/13537

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