Analysis of the 5’ untranslated region of human UPF1 mRNA indicates both cryptic promoter and internal ribosome entry site activity

Apart from its role in nonsense-mediated mRNA decay, a mechanism that promotes rapid degradation of transcripts carrying premature translation termination codons, the human up-frameshift 1 (UPF1) DNA and RNA helicase protein plays a crucial role in telomere replication and homeostasis, and in cell c...

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Bibliographic Details
Main Author: Lacerda, Rafaela (author)
Other Authors: Marques-Ramos, Ana (author), Teixeira, Alexandre (author), Romão, Luísa (author)
Format: conferenceObject
Language:eng
Published: 2015
Subjects:
Genómica Funcional e Estrutural
Nonsense-mediated mRNA Decay (NMD)
mRNA Translation
Online Access:http://hdl.handle.net/10400.18/2715
Country:Portugal
Oai:oai:repositorio.insa.pt:10400.18/2715

Internet

http://hdl.handle.net/10400.18/2715

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