No evidence for an mtDNA role in sperm motility: data from complete sequencing of asthenozoospermic males

The first complete mitochondrial DNA (mtDNA) sequences (approximately 16,569 bp) in 20 patients with asthenozoospermia and a comparison with 23 new complete mtDNA sequences in teratoasthenozoospermic individuals, confirmed no sharing of specific polymorphisms or specific mitochondrial lineages betwe...

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Bibliographic Details
Main Author: Pereira, L (author)
Other Authors: Gonçalves, J (author), Franco-Duarte, R (author), Silva, J (author), Rocha, T (author), Arnold, C (author), Richards, M (author), Macaulay, V (author)
Format: article
Language:eng
Published: 2007
Subjects:
mtDNA
Complete sequences
Asthenozoospermia
Association
Online Access:http://hdl.handle.net/10216/109570
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/109570
Description
Summary:The first complete mitochondrial DNA (mtDNA) sequences (approximately 16,569 bp) in 20 patients with asthenozoospermia and a comparison with 23 new complete mtDNA sequences in teratoasthenozoospermic individuals, confirmed no sharing of specific polymorphisms or specific mitochondrial lineages between these individuals. This is strong evidence against the accepted claim of a major role played by mtDNA in male fertility, once supported by haplogroup association studies based on the screening of hypervariable region I. The hypothesis of maternally driven selection acting in male reproductive success must thus be treated with caution.

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