Substance P antagonist improves both obesity and asthma in a mouse model

Evidence suggests a causal relationship between obesity and asthma; however, the underlying mechanisms remain unknown. Substance P (SP), involved in neurogenic inflammation by acting through its receptor NK1-R, seems to participate in obese–asthma phenotype in mice. To evaluate the effect of a selec...

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Bibliographic Details
Main Author: Ramalho, R. (author)
Other Authors: Almeida, Joana (author), Beltrão, M. (author), Pirraco, A. (author), Costa, R. (author), Sokhatska, O. (author), Guardão, L. (author), Palmares, C. (author), Guimarães, J. T. (author), Delgado, L. (author), Moreira, A. (author), Soares, R. (author)
Format: article
Language:eng
Published: 2021
Subjects:
Animal model
Asthma
NK1-R antagonist
Obesity
Substance P
Treatment
Online Access:http://hdl.handle.net/10400.22/18592
Country:Portugal
Oai:oai:recipp.ipp.pt:10400.22/18592

Internet

http://hdl.handle.net/10400.22/18592

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