Combining hyaluronic acid with chitosan enhances gene delivery

The low gene transfer efficiency of chitosan-DNA polyplexes is a consequence of their high stability and consequent slow DNA release. The incorporation of an anionic polymer is believed to loosen chitosan interactions with DNA and thus promote higher transfection efficiencies. In this work, several...

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Detalhes bibliográficos
Autor principal: Oliveira, Ana (author)
Outros Autores: Bitoque, Diogo (author), Silva, Gabriela (author)
Formato: article
Idioma:eng
Publicado em: 2018
Assuntos:
Texto completo:http://hdl.handle.net/10400.1/12033
País:Portugal
Oai:oai:sapientia.ualg.pt:10400.1/12033