TP53 codon 72 polymorphism in susceptibility, overall survival, and adjuvant therapy response of gliomas

TP53 is a key tumor suppressor gene that encodes a transcriptional factor involved in several cellular mechanisms, including growth arrest, DNA repair, and induction of apoptosis. In addition to TP53 gene mutations, a common polymorphism, Arg72Pro, has been involved in the carcinogenesis process. Th...

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Bibliographic Details
Main Author: Lima-Ramos, Vítor (author)
Other Authors: Pacheco-Figueiredo, Luís (author), Costa, Sandra Maria Araújo da (author), Pardal, Fernando (author), Silva, Ana (author), Amorim, Júlia (author), Lopes, José Manuel (author), Reis, R. M. (author)
Format: article
Language:eng
Published: 2008
Subjects:
Science & Technology
Online Access:http://hdl.handle.net/1822/8369
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/8369

Internet

http://hdl.handle.net/1822/8369

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