Network biology approaches in the identification of novel pharmacological targets – the case of cystic fibrosis
In cystic fibrosis, the most common disease-causing mutation is F508del, which causes not only intracellular retention and degradation of CFTR, but also defective channel gating and decreased membrane stability of the small amount that reaches the plasma membrane (PM). Thus, pharmacological correcti...
| Main Author: | |
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| Other Authors: | , , , , , |
| Format: | conferenceObject |
| Language: | eng |
| Published: |
2020
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| Subjects: | |
| Online Access: | http://hdl.handle.net/10400.18/7188 |
| Country: | Portugal |
| Oai: | oai:repositorio.insa.pt:10400.18/7188 |