The mechanism through which nonsense mutations are recognized as premature translation-termination codons

About one third of the gene mutations found in human genetic disorders, including cancer, result in premature termination codons (PTCs) and the rapid degradation of their mRNAs by nonsense-mediated decay (NMD). NMD controls the quality of eukaryotic gene expression. The strength of the NMD response...

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Detalhes bibliográficos
Autor principal: Onofre, Claudia (author)
Outros Autores: Menezes, Juliane (author), Peixeiro, Isabel (author), Barbosa, Cristina (author), Romão, Luísa (author)
Formato: conferenceObject
Idioma:eng
Publicado em: 2017
Assuntos:
Premature Termination Codons (PTCs)
Nonsense-mediated Decay (NMD)
Expressão Génica
Genómica Funcional e Estrutural
Texto completo:http://hdl.handle.net/10400.18/5134
País:Portugal
Oai:oai:repositorio.insa.pt:10400.18/5134

Texto Completo

http://hdl.handle.net/10400.18/5134

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