Cytoskeleton disruption by the metabolic inhibitor 3-bromopyruvate: implications in cancer therapy

The small molecule 3-bromopyruvate (3BP), is an anticancer molecule that acts by hindering glycolysis and mitochondrial function leading to energy depletion and consequently, to cell death. In this work we have focused on understanding how the glycolytic inhibition affects cancer cell structural fea...

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Bibliographic Details
Main Author: Azevedo-Silva, J. (author)
Other Authors: Tavares-Valente, D. (author), Almeida, A. (author), Queiros, O. (author), Baltazar, Fátima (author), Ko, Y. H. (author), Pedersen, P. L. (author), Preto, Ana (author), Casal, Margarida (author)
Format: article
Language:eng
Published: 2022
Subjects:
3-Bromopyruvate
Cytoskeleton
Cancer metabolism
Breast cancer
Ciências Naturais::Ciências Biológicas
Science & Technology
Online Access:https://hdl.handle.net/1822/80184
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/80184

Internet

https://hdl.handle.net/1822/80184

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