A molecular switch in the scaffold NHERF1 enables misfolded CFTR to evade the peripheral quality control checkpoint

The peripheral protein quality control (PPQC) checkpoint removes improperly folded proteins from the plasma membrane through a mechanism involving the E3 ubiquitin ligase CHIP (carboxyl terminus of Hsc70 interacting protein). PPQC limits the efficacy of some cystic fibrosis (CF) drugs, such as VX-80...

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Detalhes bibliográficos
Autor principal: Loureiro, Cláudia (author)
Outros Autores: Matos, Ana Margarida (author), Dias-Alves, Ãngela (author), Pereira, Joana Filipa (author), Uliyakina, Irina (author), Barros, Patrícia (author), Amaral, Margarida (author), Matos, Paulo (author)
Formato: article
Idioma:eng
Publicado em: 2015
Assuntos:
Vias de Transdução de Sinal e Patologias Associadas
Fibrose Quísitica
GTPase Rac1
Protein Folding
Texto completo:http://hdl.handle.net/10400.18/3072
País:Portugal
Oai:oai:repositorio.insa.pt:10400.18/3072

Texto Completo

http://hdl.handle.net/10400.18/3072

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