Muc5ac gastric mucin glycosylation is shaped by FUT2 activity and functionally impacts Helicobacter pylori binding

The gastrointestinal tract is lined by a thick and complex layer of mucus that protects the mucosal epithelium from biochemical and mechanical aggressions. This mucus barrier confers protection against pathogens but also serves as a binding site that supports a sheltered niche of microbial adherence...

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Bibliographic Details
Main Author: Magalhães, A (author)
Other Authors: Rossez, Y (author), Robbe-Masselot, C (author), Maes, E (author), Gomes, J (author), Shevtsova, A (author), Bugaytsova, J (author), Borén, T (author), Reis, CA (author)
Format: article
Language:eng
Published: 2016
Subjects:
Adhesins, Bacterial/metabolism
Animals
Bacterial Adhesion
Fucosyltransferases/genetics
Fucosyltransferases/metabolism
Gastric Mucins/metabolism
Gastric Mucosa/metabolism
Glycosylation
Helicobacter Infections/metabolism
Helicobacter
Infections/microbiology
Helicobacter pylori/metabolism
Helicobacter pylori/physiology
Humans
Lewis Blood-Group System/metabolism
Mice, Inbred C57BL
Mice, Knockout
Mucin 5AC/metabolism
Mucus/metabolism
Polysaccharides/metabolism
Protein Binding
Online Access:https://hdl.handle.net/10216/119046
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/119046

Internet

https://hdl.handle.net/10216/119046

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