The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: implications for Alzheimer's disease

The endoplasmic reticulum (ER) is the principal organelle responsible for the proper folding/processing of nascent proteins and perturbed ER function leads to a state known as ER stress. Mammalian cells try to overcome ER stress through a set of protein signaling pathways and transcription factors t...

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Bibliographic Details
Main Author: Plácido, A. I. (author)
Other Authors: Pereira, C. M. F. (author), Duarte, A. I. (author), Candeias, E. (author), Correia, S. C. (author), Santos, R. X. (author), Carvalho, C. (author), Cardoso, S. (author), Oliveira, C. R. (author), Moreira, P. I. (author)
Format: article
Language:eng
Published: 2014
Subjects:
Alzheimer's disease
Amyloid precursor protein
Endoplasmic reticulum
Secretory pathway
Therapeutic targets
Trafficking
Online Access:http://hdl.handle.net/10316/27909
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/27909

Internet

http://hdl.handle.net/10316/27909

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